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SYMPTOMS The most common symptoms of lung cancer include: A cough that does not go away Chest pain Shortness of breath Persistent hoarseness Swelling of the neck and face Significant weight loss that cannot be explained by other factors Fatigue and loss of appetite Bloody or brown-colored sputum Unexplained fever Recurrent lung infections, such as bronchitis see bronchitis entry or pneumonia DIAGNOSIS The first step in diagnosing lung cancer is a medical history and a physical examination.